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Wearable seizure detection devices in refractory epilepsy

Journal Contribution - Journal Article

Epilepsy affects 50 million patients and their caregivers worldwide. Devices that facilitate the detection of seizures can have a large influence on a patient's quality of life, therapeutic decisions and the conduct of clinical trials with anti-epileptic drugs. This article provides an up-to-date overview and comparison between wearable seizure detection devices (WSDDs), taking into account the newly proposed standards for testing and clinical validation of devices. 16 devices were included in our comparison. The F1-score, combining the device's accurate recall and precision, was calculated for each of these devices and used to evaluate their performance. The devices were separated by development phase and ranked by F1-score from highest to lowest. We describe 16 WSDDs: 6 of which were accelerometry (ACM)-based, 3 surface electromyography-based, 1 was a wearable application of EEG, 4 had multimodal sensors and 2 other types of sensors. We observed a significant inconsistency in the description of performance measures. The devices in the most advanced development phase with the highest F1-scores incorporated ACM- and sEMG-based sensors to detect tonic-clonic seizures. This review highlights the importance of implementing standards for an optimal comparison and, therefore, improving the research and development of WSDDs. WSDDs can improve the patient's care and quality of life, decrease seizure underreporting and they could potentially prevent sudden-unexpected-death in epilepsy. We discuss the central role of the neurologist in the use of WSDDs, and why a business to business to consumer model is better than the current business to consumer model of most WSDDs.
Journal: Acta Neurologica Belgica
ISSN: 0300-9009
Issue: 6
Volume: 120
Pages: 1271 - 1281
Publication year:2020
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:0.5
CSS-citation score:2
Authors from:Higher Education
Accessibility:Closed