< Back to previous page
Project
P-STAC: Stabilizing Peptide nanoStructures with tetraThiofulvalenebased donors and ACceptors (FWOAL977)
Low molecular weight peptides can associate into nanostructured
assemblies such as peptide nanotubes or hydrogels. This self
assembly process is based on weak intermolecular interactions such
as hydrogen bonds and hydrophobic contacts. To stabilise such
assemblies this project will introduce tetrathiofulvalene(TTF)-based
donor and acceptor moieties, which have been proven to be
biocompatible.
The highly electron-rich TTF "donor" moiety can form
strong stacking interactions with electron-poor "acceptor" moieties.
This stacking interaction will not only stabilise the desired peptide
nanostructures, to achieve prolonged drug-release properties, but will
also introduce new properties into these targeted assemblies,
including redox active groups and electron transport.
assemblies such as peptide nanotubes or hydrogels. This self
assembly process is based on weak intermolecular interactions such
as hydrogen bonds and hydrophobic contacts. To stabilise such
assemblies this project will introduce tetrathiofulvalene(TTF)-based
donor and acceptor moieties, which have been proven to be
biocompatible.
The highly electron-rich TTF "donor" moiety can form
strong stacking interactions with electron-poor "acceptor" moieties.
This stacking interaction will not only stabilise the desired peptide
nanostructures, to achieve prolonged drug-release properties, but will
also introduce new properties into these targeted assemblies,
including redox active groups and electron transport.
Date:1 Jan 2020 → 31 Dec 2022
Keywords:tetrathiofulvalenes, peptide-based materials, drug delivery
Disciplines:Bio-organic chemistry, Characterisation of biologically active (macro)molecules, Organic chemical synthesis, Solid state and soft matter chemistry, Supramolecular chemistry