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Project

PTM-mediated regulation of the phage-Pseudomonas biosystem (ACES - ACEtylation bioSystems)

Modern molecular biology is founded on research of bacterial viruses or ‘bacteriophages’, providing key insights in fundamental microbiology and resulting in commonly used phage-derived biotechnological tools for research and industry.During phage infection, bacteriophages efficiently hijack the bacterial metabolism in a variety of ways, ranging from cell wall modifications, replication, transcription and translation. Our research has recently discovered a potentially novel layer of phage-based regulation, by acetylation-based post translational modification (PTM) of proteins within the infected cell.In the ACES project we will perform a systematic analysis of phage/bacteria –encoded acetyltransferases relevant to phage infection. By combining state-of-the-art proteomics and bioinformatics approaches, we will unravel the system level effect on PTMs of these enzymes and elucidate the specific function and bacterial pathways regulated by the phage. This could lead to groundbreaking insights into the phage/bacteria metabolism and is complementary to ongoing research efforts towards antibacterial design strategies and synthetic biology applications.
Date:1 Oct 2020 →  Today
Keywords:phage biology, post translational modifications, microbial molecular biology, systems biology, biochemistry
Disciplines:Microbiology not elsewhere classified, Proteomics