Hyperpolarised Magnetic Resonance of Exchangeable Protons Using Parahydrogen and Aminosilane

Efficient, room temperature hyperpolarisation of exchangeable solvent protons combining parahydrogen (p-H2), ami-nopropyldiethoxymethylsilane (APDMS) and IrCl(COD)(IMES) to generate an active aminosilane-iridium complex, broadens the capabilities of SABRE-type hyperpolarisation of protons. A primary pool of hyperpolarised exchangeable protons transfers its hyperpolarisation to co-solutes with labile protons, partly overcoming the catalytic specificity of SABRE-type spin-transfer catalysis. The silane functionality of APDMS appears to be crucial to the improvement. Their role is unprecedented in p-H2-based hyperpolarisation of nuclear spins and promises to broaden applicability of ultra-sensitive solution-state NMR spectroscopy for the detection and elucidation of molecular behaviors otherwise unde-tectable at conventional sensitivity levels.

Publication year:2020

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:2

CSS-citation score:1

Authors:International

Authors from:Higher Education

Accessibility:Open