Synthesis of a small library of a SurA hit compound, 20-40 analogues, 10 mg of each compound, at least 95% purity.

SurA is a chaperone located in the periplasm of Gram-negative bacteria that is responsible for protecting outer membrane proteins from aggregation in the periplasm and facilitating their delivery to the beta-barrel assembly machinery for folding and insertion into the outer membrane. Inhibition of SurA leads to increased sensitivity to antibiotics and reduced pathogenicity. Therefore, SurA inhibitors have the potential to treat infections with gram-negative bacteria.

Keywords:ANTIBACTERIAL, MEDICINAL CHEMISTRY

Disciplines:Infectious diseases, Medicinal chemistry

Project type:Service project