Translating individual Alzheimer genetic risk into disease phenotypes (TRIAGE). (TRIAGE)

The central hypothesis of TRIAGE is that individual genetic make-up largely accounts fot hte heterogeneity of AD clinical presentation, and that the PRS can be directly translated into specific cellular and molecular pathways that trigger and drive the diseases. Our aims are:

1. To build a map of AD clinical manifestations as a function of the PRS;
2. To identify the elements responsible for AD pathology in representative individuals across the map  by using innovative disease models focussing on microglial responses;
3. To establish a preclinical therapeutic exploration platform that can be directly linked to the PRS;
4. To generate a roadmap forwards personalized medicine to AD.