Cytosolic Ca2+ oversees the MASs production of pyruvate for the mitochondrial market

It is generally accepted that mitochondrial Ca2+ controls the pace of mitochondrial bioenergetics and thus ATP production. Szibor et al. challenge this paradigm, proposing that the balance between ATP consumption and production depends on mitochondrial pyruvate supply via the malate-aspartate shuttle (MAS) and is controlled by cytosolic Ca2+.

Publication year:2020

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BOF-publication weight:1

CSS-citation score:1

Authors from:Higher Education

Accessibility:Open