Immune-mediated hemolytic anemia associated with chronic fibrosing mediastinitis in an Arabo-Friesian horse

Subtitle:Immuungemedieerde hemolytische anemie geassocieerd met chronisch fibroserende mediastinitis bij een Arabo-Fries paard

In this report, a ten-year-old gelding with immune-mediated hemolytic anemia associated with chronic fibrosing mediastinitis of unknown origin is described. The patient suffered from chronic weight loss and intermittent diarrhea for already several months. He was presented with severe anemia, anorexia and fever of a 24-hour onset. A direct Coombs test was highly positive for IgG auto-agglutination. No evidence of an underlying process was found on clinical examination. Post-mortem examination revealed green liquid material containing food particles in the cranial mediastinum and histology suggested chronic fibrosing mediastinitis. Even though perforation of the esophagus is a plausible cause, no signs of esophageal rupture were noted on macroscopic examination. This case shows that non-responsive, immune-mediated hemolytic anemia can be due to an undetected underlying disease, such as chronic mediastinitis.

Publication year:2019

BOF-keylabel:yes

IOF-keylabel:yes

Authors:National

Authors from:Higher Education

Accessibility:Closed