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Project

Translational research-oriented technology platform for single cell analysis

Single-cell analysis has become a state-of-the-art method used in translational research. However, a major challenge in the single-cell field is to prevent unwanted cellular stress during cell isolation steps as not to perturb transcriptional processes. Current projects and future research of this translational consortium necessitate such single-cell sorting infrastructure for the rapid and gentle isolation of single cells from clinical samples. Additionally, instruments allowing quick and efficient cell capture and extraction of genetic material for downstream (multi-)omic technologies in high throughput manner, are required. For large-scale single-cell analyses, automation is mandatory to eliminate operator bias and gross batch effects, while ensuring robotic precision. As such, we opted to include operatorindependent instruments featuring a high level of automation. The new platform is vital to this consortium’s research to study the biology of cellular heterogeneity in during various diseases. This translational platform for single cell analysis should accelerate discoveries in the field of human disease by providing the highly needed access to the single-cell technologies. This will enable the consortium members as well as KU Leuven/VIB to shift to the international forefront of this rapidly moving research field. 

Date:1 May 2020 →  Today
Keywords:Single-cell analysis, robotic precision
Disciplines:Single-cell data analysis