Self-replicating mRNA as a platform for Campylobacter vaccination in chickens.

Campylobacter jejuni is the most common cause of bacterial foodborne disease. Poultry products are considered the most important source. Campylobacter colonization in broilers might be reduced by immunization-based approaches. However, an effective vaccine is not yet available.
The ultimate goal of this project is to construct and evaluate a self-replicating mRNA Campylobacter vaccine, expressing immunodominant antigens in chickens.