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Project

Directing tissue folding and morphogenesis in neural tube organoids.

Recently, new insights in the field of developmental biology have suggested a crucial role of mechanical and geometrical contributions to the early stages of embryonic development. Nevertheless, even if progression in the control of organoid growth conditions through synthetic matrices has been realized, active mechanical manipulation in time of these tissue constructs is still missing. In this project, we aim to mimic human neural tube closure by developing a novel bioengineered model system based on the application of defined pressures and generation of controlled deformations on a structured neuroepithelium layer.

Date:1 Apr 2020 →  Today
Keywords:Neural tube, Neural plate, Organoids, Stem cells, Bioengineering
Disciplines:Molecular and cellular biomechanics, Tissue and organ biomechanics, Cell, tissue and organ engineering, Stem cell biology, Embryology, Developmental neuroscience
Project type:PhD project