Macrocyclic lactones as an additional measure for malaria parasite and vector control in Ethiopia

Current malaria control measures have led to a change in vector comportment which brings a new challenge to target outdoor malaria transmission. Comparative efficacy and pharmacokinetic studies of different macrocyclic lactones (MLs) will be done in local cattle breeds targeting the vector
mosquitoes. Next, the MLs will be evaluated and compared regarding their sporontocidal and gametocytocidal effect on the malaria parasite.