Microglial heterogenecity and dynamics in the context of induced tau pathology.

The major aim of this project is to characterize the response of microglia towards tau pathology and to assess the influence they might have on disease progression. To do this in an unbiased and comprehensive manner, we will perform a longitudinal experiment in which we will analyze the transcriptome of individual microglial cells from selected brain regions of a tauopathy mouse model. This work may expose novel molecular targets that could serve for early detection or therapeutic interventions in the context of AD and other neurodegenerative disorders.

Keywords:MICROGLIA, TRANSCRIPTOMICS, MICROSCOPY, TAU

Disciplines:Data visualisation and high-throughput image analysis, Single-cell data analysis, Neurosciences not elsewhere classified