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Project

MEA impedance measurement to study biofilm tolerance, heterogeneity and clearance

Biofilms are surface-associated microbial communities that are highly tolerant against most antimicrobials and cause persistent contaminations and infections in industrial (tanks and piping systems) and medical sectors (medical implants). This PhD project contributes to the development of a novel sensor technology, based on impedance measurement by microelectrode arrays (MEA’s). This sensor allows for in vivo and in situ biofilm monitoring and prediction of its susceptibility to different types of antimicrobials. Specifically, biofilm impedance assays will be used to gain insight into (i) how tolerance-related biofilm features (biofilms stage, attachment strength, growth rate, 3D structure) affect impedance, and (ii) the extent to which impedance measurements can serve as a measure for (a) biofilm heterogeneity and (b) biofilm clearance. A broader knowledge basis will facilitate sensor optimization and implementation.

Date:18 Dec 2019 →  18 Dec 2023
Keywords:Impedance, Biofilm, Microelectrode array, Biofilm heterogeneity, Biofilm clearance
Disciplines:Bacteriology, Microbiology not elsewhere classified
Project type:PhD project