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Project
4D Protein Structure.
In our research we will investigate two recent, complementary biophysical approaches, 'native' ion mobility/mass spectrometry (IM-MS) and Vibrational Optical Activity (VOA), to investigate structure and dynamics of proteins of biomedical interest. Specifically we will benchmark these techniques against well-studied protein systems, and apply them to probe changes in the conformational and assembly space of globins and oligopeptidases.
Date:1 Jan 2013 → 31 Dec 2016
Keywords:ION MOBILITY, MASS SPECTROMETRY, PROTEIN STRUCTURE, OPTICAL SPECTROSCOPY
Disciplines:Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism