Endothelial dysfunction in chronic heart failure: a study paradigm to explore novel biomarkers and therapeutic avenues.

The present project has three main aims. The first is to determine the role of endothelial dysfunction in exercise intolerance of CHF patients and to study the effect exercise training. Secondly, we will further explore the potential role of microRNAs in endothelial dysfunction. These microRNAs are short circulating molecules that regulate gene expression. We will investigate if such microRNAs might be useful as biomarkers for exercise capacity in CHF patients. The third aim is to investigate and possibly modify crucial pathways that are responsible for the bone marrow dysfunction that is found in CHF patients. This bone marrow malfunction also affects the bone marrow derived progenitor cells that are crucial in the process of endothelial repair.

Keywords:CHRONIC HEART FAILURE, BIOMARKER

Disciplines:Systems biology, Cardiac and vascular medicine, Hematology, Laboratory medicine