< Back to previous page

Project

Identification and characterisation of genes involved in bicuspid aortic valve associated aortopathy.

Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation with a population prevalence of 1 to 2%. Ten to twenty percent of the BAV patients develop thoracic aortic aneurysms (TAA). Untreated TAA will lead to life-threatening aortic dissections and ruptures. Therefore, it is important to identify TAA in BAV patients, to monitor continuously the progression of TAA and to treat TAA. The general aim of this project is to unravel the underlying genetic basis of BAV/TAA, to characterise the identified genes and to gain insights into the pathogenic mechanisms.
Date:1 Jan 2015 →  31 Dec 2018
Keywords:AORTIC ANEURYSM, BICUSPID AORTIC VALVE, GENETICS
Disciplines:Genetics, Systems biology, Cardiac and vascular medicine, Molecular and cell biology