Defining fMRI resting state network alterations and perfusion deficits in a mouse model of Alzheimer's Disease.

The primary goal of this project is to comprehensively determine the relationship between intrinsic functional network connectivity changes and altered CBF in a mouse model of AD. Our hypothesis is that the early pathological processes in AD that lead to synaptic deficits could be reflected by aberrant functional connectivity measured by rsfMRI. Additionally, perfusion measurements using ASL, will reveal a better understanding of perfusion deficits in AD.

Keywords:MOUSE MODELS, FMRI, ALZHEIMER'S DISEASE

Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing