The pharmacological profile of homomtetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels depends on the channel's inactivation gating.

Abstract (English version) Voltage−gated K+ (Kv) channels are K+ selective membrane proteins that open, close and/or inactivate in response to changes in the membrane potential. Kv channels set the resting membrane potential and are the major contributors of the repolarizing phase of the AP. Kv channels are targeted by a wide variety of pharmacological compounds that are capable of modulating Kv channel function through several mechanisms, including modifications of the gating machinery. Although the interaction of drug compounds with the closed and open state of the channel have been extensively investigated, the contribution of inactivation gating in Kv channel pharmacology remains largely unknown. In the current project we will investigate whether the inactivation process is capable of interfering with Kv channel pharmacology.

Keywords:K-CHANNELS

Disciplines:Biophysics

Project type:Collaboration project