Structure-activity relationship study of cyclopeptide alkaloids as potential new medicines.

The general aim of this project is to combine the LC-MS and LC-NMR platform available in the Laboratory of Pharmacognosy and Pharmaceutical Analysis (Department of Pharmaceutical Sciences, University of Antwerp) for the characterisation of cyclopeptide alkaloids, a promising class of natural products, from selected plant sources, followed by their targeted isolation, andestablishment of structure-activity relationships in several pharmacological models.

Keywords:MALARIA, DIABETES, STRUCTURAL CHEMISTRY

Disciplines:Analytical chemistry, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences