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Project
Biological evaluation of 1,3-diaryltriazenes and their mechanism of action on Mycobacterium tuberculosis.
A strong anti-mycobacterial activity was found for a group of symmetrically substituted 1,3-diaryltriazenes. The compounds did not show genotoxicity and mutagenicity and the anti-mycobacterial activity was dependent on the substitution pattern. In this project we want to investigate (i) how the current lead compound can be optimized, (ii) if the compounds fulfill the WHO criteria and (iii) what the mechanism of action is of the 1,3-diaryltriazenes.
Date:1 Feb 2016 → 5 Jan 2020
Keywords:TUBERCULOSIS
Disciplines:Microbiology, Systems biology, Laboratory medicine