Genetic analysis of five candidate genes in the pathogenesis of obesity.

Obesity is a chronic condition characterized by an excess amount of adipose tissue which causes several health consequences. Numerous studies have shown that obesity is strongly influenced by genetic factors, with heritability estimates in the range of 80%. Although most of the results of GWASs have been highly reproducible, they explain merely 1.5% of the BMI variation in human populations. With this project we'll gain insight into the role of five candidate genes and we'll better understand the importance of copy number variation in the pathogenesis of obesity.

Keywords:OBESITY, MUTATION ANALYSIS, CYTOGENETICS

Disciplines:Genetics, Systems biology, Laboratory medicine, Molecular and cell biology, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other clinical sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences