Diamond-based DNA sensors: surface functionalization and read-out strategies

This article reviews the Current state-of-the art of diamond-based DNA sensors. Some general concepts involved in biosensors are introduced and applied to DNA sensors. The properties of chemically vapor deposited (CVD) diamond relevant for this application are summed up, with special attention for the stability and bio-compatibility of the material. Several routes to functionalize the diamond Surface are considered. The physical properties of the obtained DNA layers are discussed in terms of surface density and molecular conformation. Possible read-out strategies are evaluated, including optical and electronic sensing. With diamond-based DNA sensors, real-time and label-free sensing is achieved.

Publication year:2009

Keywords:FIELD-EFFECT TRANSISTORS, LABEL-FREE DETECTION, ATOMIC-FORCE MICROSCOPE, VAPOR-DEPOSITED DIAMOND, BORON-DOPED DIAMOND, SINGLE-STRANDED-DNA, OF-THE-ART, THIN-FILMS, CVD-DIAMOND, PHOTOCHEMICAL FUNCTIONALIZATION

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:1

CSS-citation score:2

Authors from:Government, Higher Education, Private

Accessibility:Open