Biofabrication of complex and vascularized tissues via hybrid bioprinting

The biofabrication of 3D biomimetic tissue analogs, which accurately mimic the properties of native tissue, have an enormous potential in biomedical applications (drug discovery, cancer research, regenerative medicine,…). A basic prerequisite for the survival, maturation and function of 3D engineered tissues is the establishment of blood vessels. The most critical challenge in complex tissue engineering is the integration of a hierarchical vascular network. This project will integrate biomimetic approaches with bioprinting by combining knowledge of self-organizing vascularized spheroids with smart (cell instructive) biomaterials for generating vascularized tissues.

Keywords:biofabrication, bioprinting, smart biomaterials, tissue engineering, vascularized tissue, spheroid

Disciplines:Tissue engineering, Biomaterials