The intestinal barrier in patients with chronic kidney disease

Chronic kidney disease is characterized by the accumulation of a significant number of metabolites in the blood, often referred to as uremic retention solutes. Part of these are generated by the gut microbial metabolism. The intestinal barrier separates these bacteria (non-self) from the internal environment (self). This barrier is complex, as it provides a fence against noxious agents, but at the same time it is permeable to beneficial products of the gut bacteria, e.g. nutrients and vitamins. Both transcellular and paracellular transport contribute to permeability of the intestinal barrier. We will study the effects of chronic kidney disease on the intestinal barrier.

Keywords:intestinal barrier, leaky gut, chronic kidney disease

Disciplines:Gastro-enterology and hepatology not elsewhere classified, Kidney diseases