Researcher
Laurens Léger
- Disciplines:Stem cell biology
Affiliations
- Department of Human Structure and Repair (Department)
Member
From1 Oct 2019 → Today
Projects
1 - 1 of 1
- Exploring molecular mechanisms underlying arrhythmogenic cardiomyopathy using human engineered heart tissueFrom16 Jan 2023 → 15 Oct 2023Funding: BOF - doctoral mandates
Publications
1 - 9 of 9
- Generation of human induced pluripotent stem cell line UGENTi001-A from a patient with Marfan syndrome carrying a heterozygous c.7754 T > C variant in FBN1 and the isogenic control UGENT001-A-1 using CRISPR/Cas9 editing(2023)
Authors: Jeffrey Aalders, Laurens Léger, Anthony Demolder, Laura Muiño Mosquera
- In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells(2022)
Authors: Jeffrey Aalders, Laurens Léger, Louis Van der Meeren, Laura Muiño Mosquera, Andre Skirtach, Sanjay Sinha
Number of pages: 1 - Photothermal nanofibres enable safe engineering of therapeutic cells(2021)
Authors: Ranhua Xiong, Dawei Hua, Jelter Van Hoeck, Dominika Berdecka, Laurens Léger, Stijn De Munter, Juan Fraire, Laurens Raes, Aranit Harizaj, Félix Sauvage, et al.
Pages: 1281 - 1291 - Liquid marbles : a cost-effective platform to generate cardiospheres from co-cultured cardiomyocytes and cardiac fibroblast for disease modelling(2021)
Authors: Jeffrey Aalders, Laurens Léger, Sergio Ledda
Number of pages: 1 - Effects of fibrillin mutations on the behaviour of heart muscle cells in Marfan syndrome(2021)
Authors: Jeffrey Aalders, Laurens Léger, Louis Van der Meeren, Andre Skirtach, Sanjay Sinha
Number of pages: 1 - Use of transparent liquid marble : microbioreactor to culture cardiospheres(2021)Series: Methods in Molecular Biology
Authors: Jeffrey Aalders, Laurens Léger, Davide Piras, Sergio Ledda, Tiziana Brevini, Alireza Fazeli, Kursad Turksen
Pages: 85 - 102 - In vitro modelling of Marfan related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells(2021)
Authors: Jeffrey Aalders, Laurens Léger, Louis Van der Meeren, Andre Skirtach, Sanjay Sinha
Number of pages: 1 - Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome(2020)
Authors: Jeffrey Aalders, Laurens Léger, Louis Van der Meeren, Natasja Van den Vreken, Andre Skirtach, Sanjay Sinha, Julie De Backer, Jolanda van Hengel
- Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling(2020)
Authors: Jeffrey Aalders, Laurens Léger, Sergio Ledda