Researcher
Niels Vander Elst
- Keywords:Protein Engineering, Bacteriophage-derived enzymes, Veterinary microbiology, Bovine mastitis
- Disciplines:Veterinary microbiology, Medical molecular engineering of nucleic acids and proteins, Biocatalysis and enzyme technology
Affiliations
- Department of Veterinary and Biosciences (Department)
Member
From1 Oct 2021 → Today - Department of Pharmacology, Toxicology and Biochemistry (Department)
Member
From1 Jan 2019 → 30 Sep 2021
Projects
1 - 1 of 1
- Engineering of chimeric bacteriophage-derived endolysins and selection of staphylolytic and streptolytic candidates for the treatment of Gram-positive mammary gland infections in cows.From1 Nov 2019 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
Publications
1 - 10 of 12
- Endolysin NC5 improves early cloxacillin treatment in a mouse model of Streptococcus uberis mastitis(2024)
Authors: Niels Vander Elst, Julie Bellemans, Rob Lavigne, Yves Briers, Evelyne Meyer
- Development of engineered endolysins with in vitro intracellular activity against streptococcal bovine mastitis‐causing pathogens(2023)
Authors: Niels Vander Elst, Joni Bert, Herman Favoreel, Rob Lavigne, Evelyne Meyer, Yves Briers
Pages: 2367 - 2386 - Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis : a proof-of-concept study(2023)
Authors: Niels Vander Elst, Julie Bellemans, Jonas Steenbrugge, Chloë Geeroms, Koen Breyne, Sofie Piepers, Bruno Toledo Silva, Fernando Nogueira De Souza, Freddy Haesebrouck, Sarne De Vliegher, et al.
- One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer(2022)
Authors: Jonas Steenbrugge, Julie Bellemans, Niels Vander Elst, Josephine De Vliegher, Timothy Perera, Ward De Spiegelaere, Niek Sanders
- Splenic immunomodulatory effects of cisplatin in an immunocompetent intraductal model for triple-negative breast cancer(2021)
Authors: Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Josephine De Vliegher, Annegret Van der Aa, Eric Ciamporcero, Timothy Perera, Evelyne Meyer
Number of pages: 1 - Unexpected effects of a selective and potent c-MET inhibitor in an immunocompetent intraductal model for triple-negative breast cancer(2021)
Authors: Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek Sanders, Wim Van Den Broeck, Annegret Van der Aa, Eric Ciamporcero, Timothy Perera, Evelyne Meyer
Number of pages: 1 - Characterization of the bacteriophage-derived endolysins PlySs2 and PlySs9 with in vitro lytic activity against bovine mastitis streptococcus uberis(2020)
Authors: Niels Vander Elst, Sara B. Linden, Rob Lavigne, Evelyne Meyer, Yves Briers, Daniel C. Nelson
- Enterobactin deficiency in a coliform mastitis isolate decreases its fitness in a murine model : a preliminary host-pathogen interaction study(2020)
Authors: Niels Vander Elst, Koen Breyne, Jonas Steenbrugge, Amanda Jane Gibson, David George Emslie Smith, Pierre Germon, Dirk Werling, Evelyne Meyer
- Development of the PlyC endolysin as a bovine mastitis therapeutic for lactating dairy cows(2019)
Authors: Sara B Linden, Cynthia M Scholte, Niels Vander Elst, Kasey M Moyes, Daniel C Nelson
Number of pages: 1 - Comparative profiling of metastatic 4T1- vs. non-metastatic Py230-based mammary tumors in an intraductal model for triple-negative breast cancer(2019)
Authors: Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek Sanders, Wim Van Den Broeck, Luc Dirix, Steven Van Laere, Evelyne Meyer