Agreement between Hasselt University and PHL on the doctoral of Kenneth Verboven with title "Cariorespiratoire rehabilitation" (R-4476)

The contribution of endocrine hormones in the regulation of lipolysis during endurance exercise in subjects with obesity, and the impact of long-term exercise intervention, remains inconclusive. It is however important to understand this to maximize the impact of exercise intervention on adipose tissue mass loss in the obese, and hereby to contribute to greater primary cardiovascular disease prevention. In this project, the sensitivity of visceral and subcutaneous abdominal adipocytes for exercise-related hormones, which affect lipolysis, will be examined in lean and obese males. Next, the change in target endocrine hormones will be examined during acute endurance exercise in obese and lean males, with direct correlations towards ex vivo measured lipolysis. One will also investigate the impact of a long-term lifestyle intervention (exercise intervention) on the hormonal response to acute endurance exercise in obese males. This study will determine whether we can treat a disturbed hormonal response to exercise in the obese, and what strategies can be implemented in the prevention and treatment of obesity and cardiovascular disease.

Keywords:Endocrine hormones, Exercise intervention, lipolysis, Obesity

Disciplines:Basic sciences, Clinical sciences, Translational sciences