Project
Pathogenesis of lymphoid follicle formation and mucosal immunity in Chronic Obstructive Pulmonary Disease
An abnormal inflammatory response to cigarette smoke is a key feature of chronic obstructive
pulmonary disease (COPD), the fourth leading cause of death worldwide. Importantly, even after
smoking cessation the inflammation persists and the lung function of patients further declines.
Lymphoid follicle formation is associated with disease severity, not only in COPD but in several other
chronic inflammatory diseases. This suggests that lymphoid follicles play a role in the persistence of
inflammation. Unravelling the mechanisms of lymphoid follicle formation can contribute to a new
therapeutic strategy that targets lymphoid follicle formation in chronic inflammatory diseases.
We hypothesize that an altered crosstalk between memory B-cells and fibroblasts drives the
formation of lymphoid follicles. Furthermore, we anticipate that chronic infection with Haemophilus
influenzae U+2013which is present in 30% of patients with COPD U+2013further facilitates the development of
lymphoid follicles. Finally, we will investigate whether defective mucosal IgA immunity U+2013as seen in
patients with COPD U+2013additionally enhances lymphoid follicle formation.