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Inflammation is related to worse self-perceived fatigue in obese boys and girls

Book Contribution - Book Chapter Conference Contribution

Introduction: CRP is an inflammatory marker produced in the liver in response to factors released by macrophages and adipocytes. In previous studies it has been related to obesity in as well adults as in adolescents. After an intervention CRP was positive related with decreased Fat%. Because weight loss is related to improved cardiovascular parameters and quality of life, this study examined the relation between hs-CRP and self-perceived fatigue in obese boys and girls.
Methods: 237 obese adolescents (140 girls and 97 boys) were examined for body composition (DXA), self-perceived fatigue (Multidimensional Fatigue Inventory, MFI-20). Blood samples were collected and analyzed for hs-CRP, triglycerides (TG), cholesterol (CH), high density lipoproteins (HDL) and low density lipoproteins (LDL).
Results: Girls have a lower body weight and show more beneficial results concerning hs-CRP, HDL and systolic blood pressure (sys BP) compared to boys. Boys on the other hand show lower values for self-perceived fatigue. No significant difference was found between the 2 sexes for absolute fat mass, but girls showed significant higher fat percentage and lower lean mass than boys. Hs-CRP showed positive relations with weight, BMI, heart rate, sys BP and segmental and total fat parameters and self-perceived fatigue. An inverse relation was found for segmental and total lean%.
Conclusion: Based on our results we can state that high hs-CRP is not only related to fat accumulation and cardiovascular risks but also related to worse self-perceived fatigue. Further studies are necessary to evaluate whether self-perceived fatigue is affected by weight loss and/or physical exercise interventions.
Book: European Congress on Obesity (ECO 2015)
Pages: 110
Number of pages: 1
ISBN:978-3-318-05493-4
Publication year:2015
  • VABB Id: c:vabb:416947
  • ORCID: /0000-0002-6820-9586/work/75885415
  • ORCID: /0000-0002-7085-535X/work/76554146
  • ORCID: /0000-0002-2588-2463/work/77516891