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Publication
Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls
Journal Contribution - Journal Article
BACKGROUND AIMS: Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS).
METHODS: We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls.
RESULTS: Except for an increase in the number of C-C chemokine receptor 7-expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells.
CONCLUSIONS: Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.
Journal: Cytotherapy
ISSN: 1465-3249
Issue: 7
Volume: 16
Pages: 1024-1030
Publication year:2014
Keywords:Adult, Aged, Cell Differentiation, Dendritic Cells, Female, Humans, Immunotherapy, Lymphocyte Activation, Male, Middle Aged, Monocytes, Multiple Sclerosis, Receptors, CCR7, T-Lymphocytes, Vaccination