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Preparation and evaluation of mesoporous silica layers on radially elongated pillars

Journal Contribution - Journal Article

The present paper describes the application of a sol-gel procedure on radially elongated pillars (REPs) using tetramethoxysilane and methyltrimethoxysilane. After octadecylsilylation, the quality of the porous layered REP (PLREP) columns was evaluated by in-situ determination of migration velocities and band broadening of coumarin dyes with fluorescence microscopy in reversed-phase liquid chromatography. Based on the increase in retention due to the sol-gel process, an increase in accessible specific surface by a factor of 112 was observed. Argon physisorption measurements on bulk monoliths prepared with the same method revealed a predominant pore size of 91 Å. Plate heights as low as 0.4–0.8 μm (k = 0–1.97) could be obtained thanks to the very low dispersion of the REP format and to the fact that the applied silica layer was conformally and uniformly deposited on the flow-through channels. A kinetic plot analysis demonstrated that the studied PLREP column will deliver more theoretical plates per unit of time than a 5 μm core shell packed bed when more than 1.0 × 10 4 theoretical plates are required.

Journal: Journal of chromatography
ISSN: 0021-9673
Volume: 1523
Pages: 234-241
Publication year:2017
Keywords:Kinetic performance, Mesoporous silica layer, Pillar array column, Radially elongated pillar, Retention, Sol-gel processing
CSS-citation score:1
Accessibility:Open