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Prevalence of subtilase cytotoxin in verocytotoxin-producing Escherichia coli isolated from humans and raw meats in Belgium

Journal Contribution - Journal Article

Abstract Recently, subtilase cytotoxin (SubAB) was
detected in verocytotoxin-producing Escherichia coli
(VTEC) that do not carry the Locus of Enterocyte
Effacement (LEE) pathogenicity island. The distribution
of the subA gene in VTEC isolated from patients with the
hemolytic uremic syndrome, patients with diarrheal disease
and raw meats from ruminants and wildlife in Belgium was
investigated with PCR. The subA gene was detected more
frequently (chi2=10.2; d.f.=1; P=0.001) in VTEC from raw
meats (10 of 87 strains) than in those from humans (8 of
274 strains), and never in serogroups O157, O26, O103,
O111 and O145. This virulence marker could play a role in
the development of HUS after infection with LEE-negative
VTEC but was only found in one O178:H19 isolate out of
36 HUS-associated VTEC strains.
Journal: European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
ISSN: 0934-9723
Volume: 29
Pages: 1395-1399
Publication year:2010
Keywords:VTEC, subtilase cytotoxin, prevalence
  • ORCID: /0000-0002-7756-3691/work/61225951
  • Scopus Id: 78449258218