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Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle.

Journal Contribution - Journal Article

OBJECTIVE: To assess whether there is a difference in the ongoing pregnancy rate after transferring frozen-thawed embryos in natural cycles with spontaneous LH-P rise compared with natural cycles controlled by hCG for final oocyte maturation and ovulation. DESIGN: Randomized controlled trial. SETTING: Tertiary referral center. PATIENT(S): A total of 168 patients were assigned randomly to undergo frozen ET on day 3 from October 2007 until November 2008. Finally, analysis was performed in 124 patients; 61 belonged to the spontaneous LH group and 63 to the hCG group. INTERVENTION(S): In the spontaneous LH group the transfer was planned 5 days after the LH surge. In the hCG group, the cryopreserve ET was planned 5 days after the administration of 5000 IU of hCG, when an endometrial thickness of >/=7 mm and a follicle of >/=17 mm were present on ultrasound examination. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate. RESULT(S): The study was terminated early, when a prespecified interim analysis found a significantly higher ongoing pregnancy rate in the spontaneous LH group as compared with the hCG group (31.1% vs. 14.3%; difference 16.9%, 95% confidence interval 4.4%-28.8%). CONCLUSION(S): The results suggest the superiority of the natural cycle as compared with the natural cycle controlled by hCG administration in cryothawed ET cycles.
Journal: Fertil. Steril.
ISSN: 0015-0282
Volume: 94
Pages: 34-34
Publication year:2010
Keywords:Cryopreserved-thawed human embryo transfer
Accessibility:Closed