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The Impact of Combining a Low-Tube Voltage Acquisition with Iterative Reconstruction on Total Iodine Dose in Coronary CT Angiography

Journal Contribution - Journal Article

OBJECTIVES: To assess the impact of combining low-tube voltage acquisition with iterative reconstruction (IR) techniques on the iodine dose in coronary CTA.

METHODS: Three minipigs underwent CCTA to compare a standard of care protocol with two alternative study protocols combining low-tube voltage and low iodine dose with IR. Image quality was evaluated objectively by the CT value, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) in the main coronary arteries and aorta and subjectively by expert reading. Statistics were performed by Mann-Whitney U test and Chi-square analysis.

RESULTS: Despite reduced iodine dose, both study protocols maintained CT values, SNR, and CNR compared to the standard of care protocol. Expert readings confirmed these findings; all scans were perceived to be of at least diagnostically acceptable quality on all evaluated parameters allowing image interpretation. No statistical differences were observed (all p values > 0.11), except for streak artifacts (p = 0.02) which were considered to be more severe, although acceptable, with the 80 kVp protocol.

CONCLUSIONS: Reduced tube voltage in combination with IR allows a total iodine dose reduction between 37 and 50%, by using contrast media with low iodine concentrations of 200 and 160 mg I/mL, while maintaining image quality.

Journal: BioMed Research International
ISSN: 2314-6133
Volume: 2017
Publication year:2017
  • DOI: https://doi.org/10.1155/2017/2476171
  • WoS Id: 000402177500001
  • Scopus Id: 85021733605
  • ORCID: /0000-0003-3985-3249/work/60543232
  • ORCID: /0000-0002-8937-9488/work/61225729
  • ORCID: /0000-0003-2830-6899/work/61469296
  • ORCID: /0000-0003-3345-4431/work/61830567
  • ORCID: /0000-0002-8652-2859/work/62174813
  • ORCID: /0000-0001-5533-3185/work/62884104
  • ORCID: /0000-0002-3601-3212/work/91494436
  • PubMed Central Id: PMC5460391
CSS-citation score:1
Authors:Regional
Accessibility:Open