Priority lane to cDC1 open for IRF8⁺ progenitors

Subtitle:Priority lane to cDC1 open for IRF8(+) progenitors

In this issue of Blood, Kurotaki et al demonstrate that IRF8 expression delineates a subset of lymphoid-primed multipotent progenitors (LMPPs) biased toward the generation of conventional type 1 dendritic cells (cDC1s) by epigenetically priming the precursors for the expression of dendritic cell (DC) lineage genes.(1)

Publication year:2019

Accessibility:Closed