AcCEPT:adaptive cost effective proton therapie

External beam radiotherapy aims at delivering a curative dose to tumours while safeguarding healthy tissues. In the lung, this objective is challenged by the close presence of critical organs and breathing motion.Protons display appealing features to help reaching that goal: they show a reduced dose before a steep rise immediately followed by a sharp fall-off (Bragg-peak&rdquo). The precision ot the Bragg peak yields its major challenge: any uncertainty on its position may cause dramatic tumours/organs-at-risk under/over -exposure, particularly the tumours of the thorax. Treatment plans can be made robust to these uncertainties, inevitably with an increase of high-dose volumes. Treatment plans can also be continously adapted to the actual anatomy, i.e. online adaptation. This however is workflow demanding an has a cost; This project aims at optimizing the trade-off between both aspects.