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Project

Classical and non-classical actions of androgens and their receptor

Androgens have their well-known classical role in the development and homeostasis of the classical androgen target organs like the male reproductive organs and accessory sex glands. They also have many pleiotropic effects on non-classical organs like bone, muscle, kidney and brain. This C1 application brings together molecular biologists, endocrinologists, nephrologists and urologists as an interdisciplinary study group, with special interests in both classical and non-classical target effects. The focus of this grant application is on the molecular biology of the androgen receptor and androgens (WP1), their actions on the musculoskeletal system and kidney (WP2), their possible role in the calcification paradox in kidney disease and the molecular effects of androgen deprivation in high-risk prostate cancer (WP3).
Date:1 Oct 2019 →  30 Sep 2023
Keywords:androgens, androgen receptor, sex steroids, rodent models, chronic kidney disease, prostate cancer
Disciplines:Endocrinology