In silico modeling of the influence of scaffold properties on the in vivo tissue regeneration response in large skeletal defects

Bone tissue engineering (TE) uses a combination of cells, biomaterials and growth factors for the treatment of large bone defects, meaning that we have several processes occurring at tissue, cell and intracellular levels together. In order to understand them and be able to predict their behavior, multiscale mathematical models can be used. So far, some successful results have been published, but bone TE still suffers from unpredictable and qualitatively inferior results. In this thesis we will combine a detailed description of a biomaterial behavior in vivo with an in silico model of the biological response to said biomaterial, with the aim to generate an enhanced bioregulatory model which can predict highly qualitative TE solutions.