The role of the IRE-­1/XBP-­1 axis in NK cell mediated anti-­tumor immunology

This project aims to identify the role of the unfolded protein response in NK cell homeostasis and functioning. More specifically, we will address the function of the IRE-­1/XBP-­1 axis in NK cell mediated anti-­tumor responses in vivo. This research question is highly novel and will lead to a better understanding of NK cellbiology, which is highly relevant for cancer immunotherapy.