< Back to previous page

Project

Controlled delivery of connexin43 mimetic peptide by nanocontainers for therapy of systemic inflammation

Acute systemic inflammation is often associated with many severe life- threatening diseases. We found that connexin43 mimetic peptides are effective when applied prophylactically, while they lose their effectiveness when injected after the onset of systemic inflammation. We aim to develop nanocontainers capable of high loading of connexin43 peptides and their sustained release to ameliorate the signs of systemic inflammation.

Date:1 Oct 2018 →  31 Jul 2023
Keywords:systemic inflammation, delivery systems, connexin mimetic peptide, polymers, TNF, nanocontainers
Disciplines:Other paramedical sciences not elsewhere classified, Cell therapy, Ceramic and glass materials not elsewhere classified, Palliative care and end-of-life care, Other basic sciences not elsewhere classified, Laboratory medicine not elsewhere classified, Innate immunity, Paediatric nursing, Regenerative medicine not elsewhere classified, Clinical microbiology, Materials science and engineering not elsewhere classified, Other materials engineering not elsewhere classified, Immunogenetics, Other health sciences not elsewhere classified, Nanomaterials, Palliative care and end-of-life care not elsewhere classified, Immunology not elsewhere classified, Other translational sciences not elsewhere classified, Other clinical sciences not elsewhere classified