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The photopolymerization of DC₈,₉ in microbubbles

Journal Contribution - Journal Article

The polymerization of diacetylene lipids is a valuable mechanism that can be exploited for various applications ranging from sensor materials to triggered drug delivery. Therefore, mixtures of diacetylene lipid and saturated phospholipids have been extensively studied in liposome vesicles and Langmuir monolayers. The present study investigates the polymerization of 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC₈,₉PC) in a new assembly, i.e. in a lipid microbubble shell. Lipid microbubbles have a high degree of echogenicity which allows to probe the properties of the mixed lipid monolayer shell using ultrasound spectroscopy. Microbubbles with varying DC₈,₉PC content in a 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) matrix were characterized using ultrasound transmission spectroscopy, UV–vis absorption spectroscopy and microscopy imaging. The microbubble populations are characterized before and after UV radiation (254 nm), in order to investigate the effect of introducing DC₈,₉PC into the microbubble shell, and whether diacetylenes can polymerize in this configuration. Microbubbles were found to be more stable when either DSPC or DC₈,₉PC dominates the composition. UV radiation induced the formation of a diacetylene polymer in all DC₈,₉PC containing compositions that were investigated, and the polymerization was found to impair the stability of the microbubbles.
Journal: Colloids and Surfaces A, Physicochemical and Engineering Aspects
ISSN: 0927-7757
Volume: 568
Pages: 371 - 380
Publication year:2019
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:1
CSS-citation score:1
Authors:International
Authors from:Private, Hospital, Higher Education
Accessibility:Open