< Back to previous page

Publication

A closed-form estimator for meta-analysis and surrogate markers evaluation

Journal Contribution - Journal Article

Estimating complex linear mixed models using an iterative full maximum likelihood estimator can be cumbersome in some cases. With small and unbalanced datasets, convergence problems are common. Also, for large datasets, iterative procedures can be computationally prohibitive. To overcome these computational issues, an unbiased two-stage closed-form estimator for the multivariate linear mixed model is proposed. It is rooted in pseudo-likelihood-based split-sample methodology and useful, for example, when evaluating normally distributed endpoints in a meta-analytic context. However, applications go well beyond this framework. Its statistical and computational performance is assessed via simulation. The method is applied to a study in schizophrenia.
Journal: Journal of Biopharmaceutical Statistics
ISSN: 1054-3406
Issue: 2
Volume: 29
Pages: 318 - 332
Publication year:2019
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:0.5
CSS-citation score:1
Authors from:Higher Education
Accessibility:Open