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Project

Membrane permeation and protein targets of peroxisome-derived hydrogen peroxide

Peroxisomes have the intrinsic ability to mediate and modulate hydrogen peroxide (H2O2)‐driven signaling events. Unfortunately, the mechanisms and functional consequences of peroxisomal H2O2 (dys)regulation remain far from understood. This project is intended to address this gap. Specifically, by employing a unique and powerful cell model that can be used to selectively generate H2O2 inside peroxisomes, we will search for proteins that facilitate H2O2 permeation across the peroxisomal membrane and perform redox proteomics approaches to identify targets of peroxisome-derived H2O2. The outcomes of this study are of fundamental importance to our understanding of how alterations in peroxisomal H2O2 metabolism may drive cellular function in health and disease.

Date:1 Oct 2018 →  30 Sep 2019
Keywords:Peroxisomes, hydrogen peroxide, Oxidative modifications, Signal transduction
Disciplines:Systems biology