Association between different measures of global and local adiposity with clinico-pathological features, circulating markers, lipidomic profiles and outcome in postmenopausal breast cancer patients treated in the IBCSG 35-07 (SOLE) / BIG 1-07 trial

More than half of the Belgian women are either overweight or obese. Obese breast cancer (BC) patients are at higher risk of recurrence. In the breast, enlarged adipocytes and Crown-like Structures (CLS), composed by a dead or dying adipocytes surrounded by macrophages, have been reported as mediators of pro-inflammatory markers of adiposity. While promising, these markers have only been evaluated in relatively small and retrospective series of <150 patients. Here, we will aim at investigating the association between different measures of global (BMI) and local (CLS and size of adipocytes) adiposity with clinico-pathological features and outcome in >3,000 early postmenopausal BC patients treated in the IBCSG 35-07 (SOLE)/BIG 1-07 trial. Additionally, we will explore plasmatic circulating endocrine and inflammatory markers together with lipidomic profiles before and during treatment in ~100 of these patients to further enhance our understanding of the systemic effects of global and local adiposity