Nanopore Transistors: Characterisation and Application Development

A Field-Effect Transistor (FET) is incorporated in a Nanopore to allow for high-speed detection of biomolecule translocation. The Nanopore FET is sensitive to local potentials inside the pore and through its transconductance (transistor gain) converts these gating potentials into an easily measurable current. The performance of this device is characterized and the application of the device for protein identification is developed. The fundamental limitations on the sensitivity of sensing proteins with a Nanopore transistor are explored by combining simulation and experimental results.