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Project
Differences in DNA methylation patterns, distinct from normal age and breed-specific changes, affect the feline hypertrophic cardiomyopathy phenotype.
Whole exome sequencing will be used for the first time in cats to identify HCM-causing mutation(s) in British Shorthair cats. Next, DNA methylation patterns will be analyzed to check if specific epigenetic changes are linked to HCM and whether patterns present in blood cells can also be used as biomarker for HCM.
Date:1 Oct 2018 → 30 Sep 2022
Keywords:biomarker, whole exome sequencing, epigenetics, cat, DNA methylation, Hypertrophic cardiomyopathy (HCM), animal model
Disciplines:Cardiac and vascular medicine not elsewhere classified, Other veterinary sciences not elsewhere classified, Molecular and cell biology not elsewhere classified, Systems biology not elsewhere classified, Agricultural, veterinary and food sciences not elsewhere classified, Veterinary medicine not elsewhere classified, Genetics not elsewhere classified, Animal biology not elsewhere classified