Chemical and enzymatic bioconjugation for the site-specific decoration of proteins with therapeutic property enhancing moieties

Though biologicals have enhanced recognition and targeting capabilities, their use can be severely hampered by the fact that they are easily degraded or eliminated in a biological environment.
In the current project we aim to develop chemical and chemoenzymatic tools and methodologies for the modification of such biological molecules to enhance their properties in terms of stability, uptake in cells, circulation times and half-life.