Beurs EVDS Siebe Loontiens: Unraveling the functionality of PHF6 in normal and malignant T-cell development and its cooperativity with established oncogenes through zebrafish modeling

The research project focusses on designing a model that mimics breast cancer metastasis. Today, 90% of breast cancer (BC) death is caused by metastasis. This is largely because we are still unable to understand the mechanisms of metastatic progression. Consequently, we are unable to drug and treat to cure metastatic disease. Better models of cancer metastasis will lead to more fundamental insights. Drug evaluation using this model will enable clinicians to make more rational decisions for drug efficiency. In our project, we will reconstruct the primary breast tumor and metastatic target organs such as liver, lung and bone (the most common clinical breast cancer metastasis organs).