Liposome loaded microbubbles for the ultrasound triggered release of corticosteroids and TNF-α siRNA in the inflamed synovial tissue during rheumatoid arthritis.

Rheumatoid arthritis is an inflammatory autoimmune disease characterized by synovial inflammation. In close collaboration with the rheumatoid arthritis group we will evaluate microbubbles and ultrasound for the controlled delivery of corticosteroid and siRNA to inflamed synovial tissue. We hypothesize the use of microbubbles and ultrasound might increase the intraarticular
concentration of corticosteroids and TNF-α siRNA and reduce their side-effects.